Diamond Logo
Contact Us
Roche Cobas Integra 400 Plus Chemistry Analyzer
Roche Cobas Integra 400 Plus Chemistry AnalyzerRoche Cobas Integra 400 Plus Chemistry Analyzer

Roche Cobas Integra 400 Plus Chemistry Analyzer

Item# 0-RO-INTEGRA400+-ER

The Roche Cobas Integra 400 Plus Chemistry Analyzer, provided by Roche Diagnostics

Equipment SupportService OptionsService OptionsConsumablesConsumablesQuality ControlsQuality ControlsService PartsService Parts

Package Size: EA




Refurbished Roche cobas Integra 400 plus Chemistry Analyzer Roche's benchtop chemistry analyzer with four measuring technologies, rebuilt Down-To-Frame® to original specification. You save up to 70% compared with buying new, and you can finance with $0 down. The Roche cobas Integra 400 plus runs up to 400 tests an hour on a benchtop, with 36 tests on board, including sodium, potassium, chloride and lithium on its ISE module. Buy it refurbished from Diamond to get more mileage from your capital equipment budget. Save up to 70% compared with a new cobas Integra 400 plus. Run routine chemistry, specific proteins, therapeutic drugs, drugs of abuse and HbA1c on one analyzer, using four measuring technologies. Measure lithium on the ISE alongside sodium, potassium and chloride, so lithium monitoring doesn't need a separate analyzer. Keep up to 90 samples on board and swap reagent cassettes while the analyzer runs. Finance with $0 down and a low introductory payment, with shipping rolled into the payments. Every unit is rebuilt Down-To-Frame® by an FDA-registered, ISO 13485:2016 certified refurbisher, installed by our engineers and eligible for our service plans. REQUEST A QUOTE Refurbished Roche cobas Integra 400 plus Chemistry Analyzer installed in a laboratory by a Diamond field engineer How the cobas Integra 400 plus consolidates testing on one bench The Integra 400 plus is a random-access benchtop analyzer. Its software schedules each sample's tests to keep turnaround short, and STAT samples go in at any time, day or night. Four measuring technologies in one analyzer Absorbance photometry for enzymes and substrates: metabolic panels, liver, renal and lipid tests. Turbidimetry for specific proteins such as CRP, immunoglobulins and transferrin. Fluorescence polarization for therapeutic drug monitoring and other low-concentration assays, with a stable LED light source. ISE potentiometry for sodium, potassium, chloride and lithium. Having all four on one analyzer is what lets a small lab bring TDM, drugs of abuse and protein work in-house without buying a second instrument. Reagents 36 tests on board. 8 reagent racks hold 4 cassettes each, plus the 4 ISE tests. Automatic switch-over. Load two cassettes of a high-volume test and the analyzer moves to the second when the first runs out. Swap cassettes mid-run. Pull a cassette to make room for another test while the analyzer keeps running, and the remaining tests are saved for when it goes back on. Long on-board stability. Reagents stay usable for 2 to 6 months on board, and calibrations are infrequent, which keeps reagent waste low on tests you run a few times a week. Samples and result integrity Up to 90 samples on board in 6 sample racks, which you can swap out once their samples have been pipetted. 2 to 50 µL per test. Pressure sensors catch a bad aspiration even at 2 µL, and clotted samples are flagged right away. Clot clearing without downtime. Wash pressures are set to push clots out of the sample probe, so a clot doesn't stop the run for maintenance. Single-use cuvettes. A robotic handler loads disposable cuvettes, so there's no cuvette washing and water use stays at up to 2 L an hour. The cobas Integra 400 plus test menu Roche offers more than 120 assays and applications for the Integra 400 plus, spread across its four measuring technologies. AreaExamples Electrolytes (ISE)Sodium, potassium, chloride, lithium Metabolic and renalGlucose, BUN, creatinine, calcium, magnesium, phosphorus, uric acid Liver and pancreasALT, AST, ALP, GGT, bilirubin, albumin, amylase, lipase Lipids and cardiacCholesterol, HDL, LDL, triglycerides, CK, LDH Specific proteinsCRP, IgA, IgG, IgM, transferrin, ferritin DiabetesHbA1c, including from whole blood Therapeutic drugsDigoxin, phenytoin, carbamazepine, valproic acid, theophylline, vancomycin Drugs of abuseAmphetamines, benzodiazepines, cannabinoids, cocaine, opiates Send your menu with your quote request and we'll confirm what runs on the unit you're buying. Planning your site for a cobas Integra 400 plus A bench that can carry it. The analyzer is about 135 cm (53 in) wide and weighs about 230 kg (506 lb), heavy for a benchtop instrument. Roche sells a dedicated table for it. Make sure your bench is rated for the load. Workstation space. Leave room beside the analyzer for its PC, monitor and keyboard. Purified water. Up to 2 L an hour of Type 1 (NCCLS) water while running, so plan for a water purification system if you don't have one. Power. 100 to 125 V or 200 to 240 V AC at 50 or 60 Hz, drawing up to 1,200 VA. Dimensions (W x D x H)About 135 x 66 x 75 cm (53 x 26 x 29.5 in), analyzer only WeightAbout 230 kg (506 lb) Power100 to 125 V or 200 to 240 V AC, 50/60 Hz, 1,200 VA WaterUp to 2 L/hour, Type 1 (NCCLS) WorkstationSeparate PC, monitor and keyboard beside the analyzer Who gets the best value from a refurbished Roche cobas Integra 400 plus? Roche positions the Integra 400 plus for labs running 50 to 250 samples a day. Labs that buy it refurbished include: Small hospitals. One benchtop analyzer covers routine chemistry, electrolytes, proteins and drug levels for the ED and inpatient floors. Behavioral health and psychiatric facilities. Lithium on the ISE, plus therapeutic drug monitoring and drugs-of-abuse screens, keep medication monitoring in-house. Toxicology and pain management labs. Drugs of abuse and TDM run on the same analyzer as routine chemistry. Clinics and physician groups. Lipids, HbA1c, renal and liver panels come back the same day instead of after a send-out. Labs replacing an older Integra. Staff keep a familiar Roche platform and reagent system with a rebuilt analyzer. cobas Integra 400 plus price and what your quote covers A refurbished cobas Integra 400 plus from Diamond costs up to 70% less than a new one. We don’t list a price because your package changes your total cost: Year and software version. Later units with current Windows-based software cost more. What comes with it. Workstation PC, monitor, printer, table and starter consumables. Water system. Whether you need a Type 1 water purification system with it. Install and verification. Setup, assay verification and staff training at your site. Service plan. Platinum through Bronze, or per-visit support. Trade-in. Credit for the analyzer you're retiring. Financing Start at $0 down with a low introductory payment. Get approved on an application alone for amounts up to $400,000. Get a fast credit decision and terms that fit your budget. Roll shipping and other costs into the same payments. Send your daily sample count and menu for a quote. REQUEST A QUOTE cobas Integra 400 plus, cobas c311 or cobas pure c303? Choose the cobas Integra 400 plus if you want a benchtop analyzer that covers chemistry, proteins, TDM, drugs of abuse and lithium in one place. Choose the cobas c311 if you want a floor-standing analyzer with 45 tests on board, a 110-position sample disk and the cobas c reagents used on Roche's cobas 6000 and 8000. Choose the cobas pure c303 if you want Roche's newest small-lab platform, with c pack green reagents and room to add immunoassay. Why buy your refurbished cobas Integra 400 plus from Diamond? Diamond technician rebuilding an analyzer down to the frame beside finished refurbished analyzers All four measuring systems rebuilt and validated A used Integra 400 plus often gets checked on photometry alone, which says nothing about the fluorescence polarization unit, the ISE electrodes or the cuvette handler. Diamond rebuilds the whole analyzer to the frame, fits new probes, syringes, seals, tubing and reagent lines, and validates it with multi-level QC before it's crated. Diamond is FDA registered and ISO 9001:2015 and ISO 13485:2016 certified in the US and the EU. Installed and supported by our engineers Our engineers install the Integra 400 plus, verify your assays, lithium included, and train your staff. Every unit is eligible for our field service plans, from Platinum with next-day response to per-visit support. Preventive maintenance plans keep it on schedule at a fixed cost. Trade in your current analyzer We will consider your old analyzer for trade in value. We can also handle the deinstall and decontamination, and put its value toward your Integra 400 plus (if accepted). REQUEST A QUOTE Roche cobas Integra 400 plus FAQ Q: What is the throughput of the cobas Integra 400 plus?A: Up to 400 tests an hour. Q: How many tests can the Integra 400 plus hold on board?A: 36: 32 reagent cassettes in 8 racks, plus 4 ISE tests (sodium, potassium, chloride and lithium). Q: What measuring technologies does the Integra 400 plus use?A: Four: absorbance photometry, turbidimetry, fluorescence polarization and ISE potentiometry. Q: Is the cobas Integra 400 plus a benchtop analyzer?A: Yes, but at about 230 kg it needs a sturdy bench or Roche's dedicated table, plus space for its workstation. Q: What's the difference between the Integra 400 and the Integra 400 plus?A: The 400 plus is the later version of the Integra 400. Q: Who services a refurbished cobas Integra 400 plus?A: Diamond's own engineers, on site, under the service plan you choose.

Down-To-Frame Refurbishment Process

Factory Refurbished
FDA ISO

Upgrading or Adding Equipment to your lab?

Save up to 70% with refurbished equipment from Abbott, Alfa Wasserman, Beckman, Biomerieux, Biotechnia, Hitachi, Horiba ABX, IL, J&J, Radiometer, Randox, Roche, Siemens, Stago, Sysmex, Thermo and Tosoh.

Diamond is the only USA FDA registered, ISO Certified and Down-To-Frame® refurbisher of Chemistry, Immunology, Hematology, Caogulation and Blood Gas equipment. Inquire today for pricing and Details.

Every analyzer undergoes a systemized, rigorous and unique Down-To-Frame® Refurbishment process to rebuild each analyzer to its original specification and intended use.

Disassembly
Aesthetics
Refurbishment
Diagnostics
Validation
Final Packing
Disassembly & Decommission
  • System decommissioned from laboratory and decontaminated
  • Preliminary inspection of functionality
  • System disassembled Down-To-Frame®
Aesthetic Restoration
  • All outer covers, chassis and internal surfaces stripped, sand blasted and prepared for painting
  • All prepared surfaces primed and painted with 3 part compound, color matched automotive quality paint
  • All original logos and signage are replaced in original appearance
Refurbishment & Reassembly
  • All mechanical, pneumatic, electronic assemblies disassembled, cleaned, restored, verified and reassembled, replaced where needed
  • Disposable components replaced with new components
  • New components include: tubing, fittings, syringes, seals, check valves, probes, reagent lines, waste assemblies and similar items
  • System completely reassembled into its original condition in accordance to protocol and established specifications
Diagnostics & Troubleshooting
  • Assembly Functions & System errors assessed, troubleshooting and repair conducted
  • Full system diagnostic testing conducted
  • System successfully calibrated with certified calibrator materials to ensure proper functionality
Performance Validation
  • Rigorous Multi-Level Quality Control testing conducted on established parameters using certified control material
  • Specific parameter testing available upon request
  • System checked for power stability, software revisions and other upgrades
Final Packing
  • Required peripherals for operation refurbished or provided new as needed
  • System properly flushed, drained, protected and prepared for storage
  • System professionally crated with heat-treated and non-coniferous wood for international transit

Performance & Configuration
Assays

96 Total Assays Tested

**************(*****), ************(****), ***************(****), ************(****), ********(***), **********(*****), **********(*****), ******(****), ************(***), ***************(******), ***********(***), **************(*****), **************(******), ********(****), ************(*****), ************(****), ***************(****), ***********(***), **********(******), ***************(******), **********(*****), *******(*****), **************(***), ********(****), *******(******), ************(***), ***********(****), ***********(***), ***********(****), *********(*****), **********(***), ******(***), ***************(****), ******(*****), ***********(***), *******(*****), *******(****), **************(******), *************(***), ********(****), ***********(****), ************(*****), ************(******), ********(****), **************(*****), *********(******), ********(*****), ***************(*****), ******(****), ***************(*****), ************(******), ***************(*****), ***************(******), ***********(***), ********(******), **************(***), ************(*****), **************(******), ************(***), **************(***), ***************(******), *************(****), ***********(****), **********(****), ***************(******), ********(***), ******(******), ***********(*****), *********(***), *************(******), ************(****), *******(****), *******(***), *******(****), **************(*****), **********(*****), ***************(****), ***************(******), ******(***), ***********(****), ********(***), **********(***), ********(****), **************(***), ******(***), *************(***), ******(******), *************(****), ***************(****), ************(******), **********(*****), *************(*****), *********(***), ***************(***), ***************(***), *********(*****)

Technical Specifications
Manufacturer:Roche Diagnostics (Hoffmann)
Series:Integra
CLIA Complexity:Moderate
Sample Types:CSF, Plasma, Urine, Whole Blood, Serum, Hemolysate
Number of Assays:96
Maximum Throughput:400 tests/hour
Sample Cycle Time:11 (sec)
Sample Size Min:2 μL
Direct Sample (STAT):Yes
Auto Sample Handling:Yes
Sample Input Type:
Sample Tube
Sample Cup
Reagent Type:Liquid
Reagent System:Closed
Reagent Capacity:36 (32 cassettes + 4 ISE)
On-Board Refrigeration:Yes
Configuration:Bench Top
Height:75 cm (30 in)
Width:135 cm (53 in)
Depth:66 cm (26 in)
Weight:222 kg (488 lb)
Water Requirement:Yes
Water OnBoard Supply:No
Water Consumption:2 (L/hour)
Power Supply:110V or 220V
Point Of Care:No

All units sold by Diamond Diagnostics or units qualified by Diamond Diagnostics are eligible for Field Service coverage. Service plans are the best way to maximize your instrument investment and avoid the high costs associated with instrument failure. Our plans are designed to support optimum instrument performance, ensure reproducible results and minimize down-time. Our service plans provide a timely response from our dedicated engineers who are certified on an ongoing basis to ensure top-notch results, even in the most complex laboratory environments.

. Service OptionsPlatinumGoldSilverBronzeLaborLaborPer DiemTravelTravelPer VisitService PartsService PartsIncident TrackingIncident TrackingResponse TimeResponse TimeNext DayNext Business Day2 Business Days*First AvailablePhone SupportPhone SupportMon-Sun 0-24Mon-Sun 0-24Remote SupportRemote SupportHoliday SupportHoliday SupportPreventive MaintenancePrev Maintenance*Peripheral SupportPeripheral SupportComplimentary LoanerCompl LoanerRelocationRelocationRecommissionRecommissionDecommisionDecommisionDecontaminationDecontaminationTrainingTrainingAssay ProgrammingAssay ProgrammingIQ/OQ ValidationIQ/OQ Validation

: Included

: Chargeable

: None

* Contact for more details

Preventive Maintenance
Preventive Maintenance

For the laboratory looking to manage manufacture recommended preventative maintenance (PM) schedules for instrumentation at a fixed cost. The PM Service Plan will increase the reliability and reduce the risk and costs of unplanned maintenance and equipment downtime. Our plans are scheduled and planned around your specific instrument and operational needs.


Depot Service, Type 1
Depot Repair Per Diem

For the laboratory looking to maximize the life of their instrumentation while effectively managing repair costs. The Depot Repair is a per diem plan designed for any size instrument needing major repair, complete rebuild or recycling.


Depot Service, Type 2
Annual Depot Repair

For the laboratory looking to maximize the life of their instrumentation while effectively managing repair costs. Annual Depot Repair is an annual based plan designed for small to mid-sized instruments needing maintenance or repairs and can be easily shipped by your local carrier to our Depot Service Facility in Holliston, MA.


Phone Support
Phone Support

For the laboratory employing qualified service professionals, the Virtual Plan may be a suitable choice to replace or supplement Field Services. The Virtual plan offers its customers support by email and telephone, within business hours with communication directly with Clinical Engineering staff specialized in the model of instrumentation that the laboratory is utilizing. The Virtual Plan is annual.


Click here to learn more.

Related Products

Roche Cobas Integra 400 Plus Chemistry Analyzer

Diamond Smartlyte Plus

The names and logos of manufacturers, their instruments, and their products referred to herein may be protected by trademark or other law, and are used herein solely for purpose of reference. Products are available for international distribution only unless otherwise indicated. Diamond Diagnostics expressly disclaims any affiliation with products it does not manufacture, as well as sponsorship by other manufacturers. For current regulatory status on products within this website, please contact your sales representative. Prices and Information shown are for reference only and may change without notice. SmartLyte®, ProLyte®, CareLyte®, and Down-To-Frame® Refurbishing are Registered Trademarks of Diamond Diagnostics®. No mobile information will be shared with third parties/affiliates for marketing/promotional purposes. All the above categories exclude text messaging originator opt-in data and consent; this information will not be shared with any third parties.

©2016-2026 Diamond Diagnostics®. All Rights Reserved.